BDBM50378702 CHEMBL560895::SNX-2112

SMILES CC1(C)Cc2c(c(nn2-c2ccc(C(N)=O)c(NC3CCC(O)CC3)c2)C(F)(F)F)C(=O)C1

InChI Key InChIKey=ZFVRYNYOPQZKDG-UHFFFAOYSA-N

Data  4 KI  5 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50378702   

TargetHeat shock protein 75 kDa, mitochondrial(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 726nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetEndoplasmin(Dog)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 578nMAssay Description:Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 22nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradation in human MCF7 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 7nMAssay Description:Inhibition of HSP90-mediated client protein HER2 degradationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataEC50:  19nMAssay Description:Inhibition of HSP90alpha in human MCF7 cells assessed as degradation of Her-2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-alpha(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataIC50: 3nMAssay Description:Inhibition of Hsp90alphaMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  1.10nMAssay Description:Binding affinity to HSP90 under reducing conditions in presence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Biogen Idec

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  2.80nMAssay Description:Binding affinity to HSP90 under non-reducing conditions in absence of TECPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/29/2012
Entry Details Article
PubMed
TargetEndoplasmin(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  484nMAssay Description:Binding affinity to human N-terminal polyHis-tagged GRP94 (L69 to N337) expressed in Escherichia coli BL21(DE3) after 3 hrs by fluorescence polarizat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetHeat shock protein 75 kDa, mitochondrial(Human)
Memorial Sloan-Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50378702(SNX-2112 | CHEMBL560895)
Affinity DataKi:  791nMAssay Description:Binding affinity to human recombinant TRAP1 after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed