BDBM50532577 Avosentan::RO 67-0565::RO-67-0565::Ro670565::SPP-301::SPP301

SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(C)cn2)nc(nc1OC)-c1ccncc1

InChI Key InChIKey=YBWLTKFZAOSWSM-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50532577   

TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 1.40nMAssay Description:Displacement of 125I-ET1 from ETA receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at ETA receptor (unknown origin) in presence of ET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin-1 receptor(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at ETA receptor (unknown origin) in presence of ET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 600nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 600nMAssay Description:Displacement of radioligand from ETB receptor in human placenta cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at ETB receptor (unknown origin) in presence of ET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed
TargetEndothelin receptor type B(Human)
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50532577(Avosentan | RO 67-0565 | RO-67-0565 | Ro670565 | S...)
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity at ETB receptor (unknown origin) in presence of ET1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMed