BDBM10888 1,2-benzoxazol-3-ylmethanesulfonamide::CHEMBL750::SPR_2::US10172837, Zonisamide::Zonisamide::Zonisamide (ZNA)::Zonisamide (ZNS)::Zonisamide, 1::Zonisamide, ZNS

SMILES c1ccc2c(c1)c(no2)CS(=O)(=O)N

InChI Key InChIKey=UBQNRHZMVUUOMG-UHFFFAOYSA-N

Data  143 KI  2 IC50  3 Kd  1 Koff  1 Kon

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 148 hits for monomerid = 10888   

TargetCarbonic anhydrase 2(Bovine)
University of Dundee

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKd:  4.26E+3nM Kon:  1.43E+5M-1s-1 Koff:  0.611s-1pH: 7.4 T: 2°CAssay Description:SPR biosensor assay Biacore T100More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2000
Entry Details

TargetCarbonic anhydrase 2(Bovine)
University of Dundee

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataIC50: 1.86E+3nMpH: 7.4 T: 2°CAssay Description:In this assay, 4-nitrophenyl acetate (4-NPA), a colorless compound, was hydrolyzed to 4-nitrophenol and CO2. The reaction was followed by measuring t...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKd:  20.6nMAssay Description:Inhibition of human carbonic anhydrase 5AMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKd:  47.6nMAssay Description:Inhibition of human carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Naia Metabolic

US Patent
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataIC50: 35nMAssay Description:Compounds which are CAIs are well known in the art, see for example, Pastorekova et al, Journal of Enzyme Inhibition and Medicinal Chemistry, 19(3), ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2019
Entry Details
Go to US Patent

TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5nMAssay Description:Inhibition of human cloned CA9 catalytic domain by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5.10nM ΔG°:  -11.1kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human CA9 catalytic domain preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5.10nMAssay Description:Inhibitory constant against catalytic domain of human carbonic anhydrase IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human recombinant CA9 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  5.10nMAssay Description:Inhibition of human recombinant CA9 catalytic domain-mediated CO2 hydration preincubated for 15 mins by stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  10.3nMAssay Description:Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  20nM ΔG°:  -10.3kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant CA5A mitochondrial isoform by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant CA5A by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  20nMAssay Description:Inhibition of human recombinant CA5A by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nM ΔG°:  -10.2kcal/molepH: 7.4 T: 2°CAssay Description:Carbonic anhydrase (CA) inhibition against hCA II and V11 with synthesized compounds 2-8.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/21/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nM ΔG°:  -9.99kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/19/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 cytosolic isoform by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant alpha-carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2011
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant full length CA2 preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/21/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human cloned CA2 by CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human cloned CA2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35nMAssay Description:Inhibition of human recombinant full length CA2-mediated CO2 hydration preincubated for 15 mins by stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  35.2nMAssay Description:Mean inhibitory constant towards human carbonic anhydrase II determined by stopped-flow method after 1 hr of incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Di Biostrutture E Bioimmagini-Cnr

Curated by ChEMBL
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  41nM ΔG°:  -10.1kcal/molepH: 7.5 T: 2°CAssay Description:Phenol red (at a concentration of 0.2 mM) has been used as indicator, working at the absorbance maximum of 557 nm, with 10 mM Tris-HCl (pH 7.5) as bu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Naia Metabolic

US Patent
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  56nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Naia Metabolic

US Patent
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  56nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Naia Metabolic

US Patent
LigandPNGBDBM10888(Zonisamide, 1 | 1,2-benzoxazol-3-ylmethanesulfonam...)
Affinity DataKi:  56nM ΔG°:  -9.72kcal/molepH: 7.5 T: 2°CAssay Description:Inhibition assay using carbonic anhydrases with an SX.18MV-R, a stopped-flow instrument from Applied Photophysics was used for assaying the CA cataly...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/28/2011
Entry Details Article
PubMed
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