BDBM50065306 3-[4-(1-formylpiperazin-4-yl)benzylidenyl]-2-indolinone::4-{4-[2-Oxo-1,2-dihydro-indol-(3Z)-ylidenemethyl]-phenyl}-piperazine-1-carbaldehyde::CHEMBL315546::SU-4984

SMILES O=CN1CCN(CC1)c1ccc(\C=C2/C(=O)Nc3ccccc23)cc1

InChI Key InChIKey=ZNFJBJDODKHWED-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50065306   

LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 5.13E+3nMAssay Description:Inhibitory activity against vascular endothelial growth factor receptor 2 (FLK1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/20/2013
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
New York University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1K autophosphorylation activity assessed as [32P] incorporationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Mouse)
New York University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblottingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 5.10E+3nMAssay Description:Test concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Platelet-derived growth factor receptor beta (PDGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Insulin-like growth factor I receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.60E+3nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on murine VEGF receptor (FLK-1 RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Sugen

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.00E+5nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Epidermal growth factor receptor (EGF RTK).More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 9.02E+4nMAssay Description:Concentration required to achieve 50% inhibition of tyrosine phosphorylation on human Her-2 receptor tyrosine kinase (HER-2 RTK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Mouse)
New York University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 2.00E+4nMAssay Description:Inhibition of FGF induced FGFR1 autophosphorylation in mouse NIH 3T3 cells preincubated for 5 mins followed by FGF-stimulation for 5 mins in presence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
New York University Medical Center

Curated by ChEMBL
LigandPNGBDBM50065306(SU-4984 | 3-[4-(1-formylpiperazin-4-yl)benzylideny...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 kinase domain (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed