BDBM50051539 (S)-4-phenyl-1-(2-(pyrrolidine-1-carbonyl)pyrrolidin-1-yl)butan-1-one::4-Phenyl-1-[(S)-2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-butan-1-one::4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-1-yl]-butan-1-one::CHEMBL289651::SUAM-1221

SMILES O=C(CCCc1ccccc1)N1CCC[C@H]1C(=O)N1CCCC1

InChI Key InChIKey=HDRSLHFTJYMQIL-UHFFFAOYSA-N

Data  1 KI  18 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50051539   

TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant porcine brain PREP expressed in Escherichia coli assessed as formation of 7-amido-4-methylcoumarin using Suc-Gly-Pro-amido-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of pig PREP expressed in Escherichia coli using Z-Gly-Pro-p-nitroanilide substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Mouse)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of mouse recombinant FAP expressed in HEK293 cells assessed as pNA release from Ala-Pro-p-nitroanilide pre-incubated with enzyme for 15 mi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human seminal plasma DPP4 assessed as pNA release from Gly-Pro-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
University of Antwerp

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human seminal plasma DPP2 assessed as pNA release from Lys-Ala-p-nitroanilide substrate pre-incubated with enzyme for 15 min prior to s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetProlyl endopeptidase(Mouse)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 4.70nMAssay Description:Inhibition of mouse brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of rat brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibition of pig brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Bovine)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of bovine brain POPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/30/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 190nMAssay Description:Inhibitory activity was evaluated against Post-proline cleaving enzyme from bovine brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 2.20nMpH: 7.0Assay Description:In vitro inhibitory activity against porcine prolyl oligopeptidase by using 4 mM Suc-Gly-Pro-7-amido-4-methylcoumarin as substrate (pH 7.0) at 30 deg...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 49nMAssay Description:In vitro inhibitory activity against purified prolyl endopeptidase (PEP) from canine brain.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/27/2012
Entry Details Article
PubMed
TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 30nMAssay Description:Inhibitory activity against rat brain Prolyl endopeptidase (PEP)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetProlyl endopeptidase(Rat)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 30nMAssay Description:Inhibition of POP in Sprague-Dawley rat brain homogenatesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 2.20nMAssay Description:Inhibitory activity against prolyl oligopeptidase of porcine brain homogenateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Pig)
Mcgill University

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibitory activity against prolyl oligopeptidase (POP) from pig brain; value ranges from (1.9-2.5)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Prolyl endopeptidaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase(Human)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051539(4-Phenyl-1-[2-(pyrrolidine-1-carbonyl)-pyrrolidin-...)
Affinity DataKi:  0.970nMAssay Description:Inhibition of prolyl oligopeptidase (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2015
Entry Details Article
PubMed