BDBM50239940 CHEBI:85083::PSI-7977, GS-7977::Sofosbuvir::Sovaldi

SMILES C[C@@H](C(=O)OC(C)C)N[P@](=O)(OC[C@@H]1[C@H]([C@@]([C@@H](O1)N2C=CC(=O)NC2=O)(C)F)O)Oc3ccccc3

InChI Key InChIKey=TTZHDVOVKQGIBA-UHFFFAOYSA-N

Data  5 IC50  19 EC50

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50239940   

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  34nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetGenome polyprotein(Dengue virus)
Csir-Indian Institute of Chemical Technology (CSIR-IICT)

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataIC50: 1.47E+4nMAssay Description:Inhibition of Dengue virus NS5/RNA-dependent RNA polymeraseMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
12/19/2024
Entry Details
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  230nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b Con1 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days ...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/14/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  155nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a H77 infected in human HuH7 replicon cells assessed as inhibition of viral replication after 3 days b...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/14/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  64nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  64nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/3a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  34nMAssay Description:Inhibition of NS5B polymerase in wild type HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  61nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  300nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  58nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  43nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  43nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 2a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCytochrome P450 2C9(Human)
Emory University

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of human CYP2C9 using sulfaphenazole as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/27/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  61nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1a infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  44nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  58nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/4a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  300nMAssay Description:Inhibition of NS5B polymerase S282T mutant in HCV genotype 1b infected in human Huh7 replicon cells after 5 days by RT-PCR assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  44nMAssay Description:Inhibition of NS5B polymerase in HCV genotype 1b/5a chimeric replicon infected in human HuH7 replicon cells after 5 days by RT-PCR analysisMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/26/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetGenome polyprotein(ZIKV)
University of North Carolina at Chapel Hill

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  120nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus infected in human NPC assessed as antiviral activity by DAPI-staining based assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/21/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetGenome polyprotein(ZIKV)
University of North Carolina at Chapel Hill

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  3.09E+4nMAssay Description:Inhibition of RNA-dependent RNA polymerase in Zika virus infected in African green monkey Vero cells assessed as antiviral activity by DAPI-staining ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
2/21/2021
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetRNA-directed RNA polymerase(Hepatitis C virus genotype 1b (isolate Con1) (HCV))
Emory University School of Medicine

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataEC50:  64nMAssay Description:Inhibition of Hepatitis C virus genotype 1b NS5B RNA-dependent-RNA polymerase assessed as reduction in viral replication after 72 hrs by indirect imm...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
8/17/2020
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCytochrome P450 1A2(Human)
Emory University

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2 using alpha-naphthoflavone as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/27/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCytochrome P450 3A4(Human)
Emory University

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of human CYP3A4 using ketoconazole as substrateMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/27/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetCytochrome P450 2D6(Human)
Emory University

Curated by ChEMBL

LigandBDBM50239940(CHEBI:85083 | PSI-7977, GS-7977 | Sofosbuvir | Sov...)Copy SMILESCopy InChI

Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6 using quinidine as substrateMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPurchaseChEBI
PC cidPC sidPDBSimilars

In Depth
Date in BDB:
9/27/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL