BDBM50022784 (R)-N-methyl-3-phenyl-3-(o-tolyloxy)propan-1-amine::ATOMOXETINE::CHEMBL641::Methyl-((R)-3-phenyl-3-o-tolyloxy-propyl)-amine::Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine::Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxetine)::Strattera::Tomoxetine

SMILES CNCCC(Oc1ccccc1C)c1ccccc1

InChI Key InChIKey=VHGCDTVCOLNTBX-UHFFFAOYSA-N

Data  79 KI  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 87 hits for monomerid = 50022784   

TargetCytochrome P450 2D6(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 180nMAssay Description:Inhibition of serotonin uptake at human SERT transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of norepinephrine uptake at human NET transfected in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 180nMAssay Description:Inhibition of serotonin uptake at human SERT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 5nMAssay Description:Inhibition of norepinephrine uptake at human NET expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of dopamine uptake at human DAT expressed in HEK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
Johnson and Johnson Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibitory activity against Opioid receptor like 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  2.03nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  8.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  77nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  750nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/26/2011
Entry Details
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Mayo Clinic

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  940nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2011
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSubstance-K receptor(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSubstance-P receptor(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetMelatonin receptor type 1A(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetHistamine H2 receptor(Guinea pig)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetGlycine receptor subunit alpha-1(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetGlutamate receptor 3(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetNeuromedin-K receptor(Mouse)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetNeuropeptide Y receptor type 1(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5'-nucleotidase(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetProtein kinase C alpha type(Mouse)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Guinea pig)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetSomatostatin(Rat)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1B(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1D(Human)
Eli Lilly

Curated by PDSP Ki Database
LigandPNGBDBM50022784(Methyl-(3-phenyl-3-o-tolyloxy-propyl)-amine(tomoxe...)
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/13/2012
Entry Details Article
PubMed
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