BDBM50543112 Evofosfamide::HAP-302::TH-302

SMILES Cn1c(COP(=O)(NCCBr)NCCBr)cnc1[N+]([O-])=O

InChI Key InChIKey=UGJWRPJDTDGERK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50543112   

TargetAlpha-enolase(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50543112(Evofosfamide | HAP-302 | TH-302)
Affinity DataIC50: 2.55E+3nMAssay Description:Inhibition of ENO1 in overexpressed human D423 cells incubated for 5 days in presence of 21 % oxygen by crystal violet staining based spectrophotomet...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-enolase(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50543112(Evofosfamide | HAP-302 | TH-302)
Affinity DataIC50: 4.84E+3nMAssay Description:Inhibition of ENO1 in wild-type human LN319 cells incubated for 5 days in presence of 21 % oxygen by crystal violet staining based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-enolase(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50543112(Evofosfamide | HAP-302 | TH-302)
Affinity DataIC50: 301nMAssay Description:Inhibition of ENO1 in overexpressed human D423 cells incubated for 5 days in presence of 1 % oxygen by crystal violet staining based spectrophotometr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed
TargetAlpha-enolase(Human)
University of Texas Md Anderson Cancer Center

Curated by ChEMBL
LigandPNGBDBM50543112(Evofosfamide | HAP-302 | TH-302)
Affinity DataIC50: 897nMAssay Description:Inhibition of ENO1 in wild-type human LN319 cells incubated for 5 days in presence of 1 % oxygen by crystal violet staining based spectrophotometryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/13/2021
Entry Details Article
PubMed