BDBM50176263 3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol::CHEMBL1400::O-DESMETHYL TRAMADOL::Ultracet::rel-3-((1R,2R)-2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol

SMILES CN(C)C[C@H]1CCCC[C@]1(O)c1cccc(O)c1

InChI Key InChIKey=UWJUQVWARXYRCG-UHFFFAOYSA-N

Data  9 KI  6 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50176263   

TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 47nMAssay Description:Binding affinity to mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at MOR (unknown origin) expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS binding measured after 60 mins by ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetMu-type opioid receptor(Rat)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataEC50:  245nMAssay Description:Agonist activity at rat mu opioid receptor expressed in CHO cells incubated for 1 hr by [35S]GTPgammaS binding based liquid scintillation counting me...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataEC50:  120nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 1 hr by HTRF ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of NET mediated norepinephrine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of SERT mediated 5-hydroxytryptamine uptakeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of reuptake of 5HTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 47nMAssay Description:Inhibition of mu opioid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of reuptake of NorepinephrineMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataEC50:  240nMAssay Description:Agonist activity at human MOR expressed in CHO cell membranes after 60 mins by [35S]GTP-gamma-S binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  8.60nMAssay Description:Activity at human cloned mu opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]naloxone from human MOR expressed in CHO-K1 cell membranes after 60 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
Sepracor

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DAMGO from human MOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-DAMGO from rat mu opioid receptor expressed in CHO cells incubated for 30 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2022
Entry Details Article
PubMed
TargetMu-type opioid receptor(Mouse)
Fudan University

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H] DAMGO from mouse MOR expressed in CHO cell membrane incubated for 90 mins by scintillation methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  450nMAssay Description:Activity at human cloned kappa opioid receptor expressed in CHO cells by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi:  2.90E+3nMAssay Description:Displacement of [3H]Naltrindole form human delta opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/18/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPDPE from human DOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
Rensselaer Polytechnic Institute

Curated by ChEMBL
LigandPNGBDBM50176263(CHEMBL1400 | rel-3-((1R,2R)-2-((dimethylamino)meth...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]U69593 from human KOR expressed in CHO cell membranes after 60 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/11/2017
Entry Details Article
PubMed