BDBM50296485 (R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)methoxy]azetidin-1-yl}piperidin-1-ylmethanone::CHEMBL558709::VER-156085

SMILES Clc1ccc(cc1)[C@@H](OC1CN(C1)C(=O)N1CCCCC1)c1cccnc1Cl

InChI Key InChIKey=QEKKZTBXSULKCC-UHFFFAOYSA-N

Data  3 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50296485   

TargetCannabinoid receptor 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  7nMAssay Description:Displacement of [3H]SR141716A from human CB1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH incubated 1 hr prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH incubated 3 hrs prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAAH incubated 1 hr prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAAH incubated 3 hrs prior to addition of arachidonyl-amino-methyl-coumarin amideMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  1.09E+4nMAssay Description:Displacement of [3H]CP-55940 from human CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/27/2010
Entry Details Article
PubMed
TargetCannabinoid receptor 2(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataKi:  1.09E+4nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1 [30-579](Rat)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of rat FAAH using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed
TargetFatty-acid amide hydrolase 1(Human)
Vernalis (R&D)

Curated by ChEMBL
LigandPNGBDBM50296485((R)-{3-[(4-Chlorophenyl)-(2-chloropyridin-3-yl)met...)
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human FAAH expressed in CHO cells using 7-amino-4-methylcoumarine amide as substrate preincubated for 1 hr by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/23/2012
Entry Details Article
PubMed