BDBM50300828 2-(3-(3-fluorophenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)-N,N-dimethylethanamine::CHEMBL571858::N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridin-1-yl}ethyl)-N,N-dimethylamine::WAY-208466

SMILES CN(C)CCn1cc(c2cccnc12)S(=O)(=O)c1cccc(F)c1

InChI Key InChIKey=SFSFIDVAEMDPIP-UHFFFAOYSA-N

Data  5 KI  5 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 13 hits for monomerid = 50300828   

Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataIC50: 644nMAssay Description:Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataIC50: 4.76E+3nMAssay Description:Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataIC50: 5.00E+3nMAssay Description:Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataEC50:  7.30nMAssay Description:Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataIC50: 351nMAssay Description:Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human 5-HT6 receptor expressed in HeLa cells by scintillation counterMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2016
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]LSD from human cloned 5HT6 receptor expressed in HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H] LSD from 5-HT6R in human HeLa cells assessed as inhibition constant incubated for 120 mins in presence of methiothepin by scinti...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/26/2023
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.80nMAssay Description:Displacement of [3H]-LSD from human 5-HT6 receptor expressed in human HeLa cells assessed as inhibition constant incubated for 120 mins by Topcount s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 6(Human)
University of Caen Normandie

Curated by ChEMBL
LigandPNGBDBM50300828(N-(2-{3-[(3-Fluorophenyl)sulfonyl]-1H-pyrrolo[2,3-...)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]LSD from human HT6 receptor expressed in human HeLa cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/30/2010
Entry Details Article
PubMed