BDBM504322 US11040968, Example 004::WX004

SMILES Cc1cc(F)c(cc1-n1nnc(n1)C1CC1)C(=O)Nc1cccc(n1)-c1nnc2CCCCn12

InChI Key InChIKey=LNASMLOVUYYHOP-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504322   

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM504322(WX004 | US11040968, Example 004)
Affinity DataIC50: 100nMAssay Description:Inhibition of full length GST-tagged recombinant human ASK1 using MBP as substrate incubated for 20 mins by cell based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM504322(WX004 | US11040968, Example 004)
Affinity DataIC50: 1.00E+3nMAssay Description:Primary reaction buffer solution: 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSOTreatme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2021
Entry Details
US Patent

TargetMitogen-activated protein kinase kinase kinase 5(Human)
Jiangxi University of Chinese Medicine

Curated by ChEMBL
LigandPNGBDBM504322(WX004 | US11040968, Example 004)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of full length GST-tagged recombinant human ASK1 using MBP as substrate incubated for 20 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed