BDBM50052022 (S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-propionate2-hydroxy-1,1-bis-hydroxymethyl-ethyl-ammonium;::CHEMBL314449::WY-50295

SMILES C[C@H](C([O-])=O)c1ccc2ccc(OCc3ccc4ccccc4n3)cc2c1

InChI Key InChIKey=OLFVZFQFBDVFLJ-UHFFFAOYSA-M

Data  1 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50052022   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50052022((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...)
Affinity DataIC50: 47nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase translocation inhibitor in RBL-2H3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50052022((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...)
Affinity DataIC50: 100nMAssay Description:The compound was tested for inhibitory activity against 5-Lipoxygenase receptor in rat polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50052022((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...)
Affinity DataIC50: 800nMAssay Description:The compound was tested for inhibitory activity against 5-lipoxygenase in human polymorphonuclear leukocytes[PMNS]More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed
TargetCysteinyl leukotriene receptor 1(Guinea pig)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50052022((S)-2-[7-(Quinolin-2-ylmethoxy)-naphthalen-2-yl]-p...)
Affinity DataKi:  2.80E+3nMAssay Description:The compound was tested for binding affinity against Cysteinyl leukotriene D4 receptor in guinea pig lung membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/22/2012
Entry Details Article
PubMed