BDBM50457451 BMS-908662::EXEL-2819::XL-281

SMILES COC(=O)Nc1nc2cc(ccc2[nH]1)C1(O)N(C(=O)c2ccccc12)c1cc(Cl)ccc1C

InChI Key InChIKey=MMNNTJYFHUDSKL-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50457451   

TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50457451(BMS-908662 | EXEL-2819 | XL-281)
Affinity DataIC50: 6nMAssay Description:Inhibition of BRAF V600E mutant (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Albert Einstein College of Medicine

Curated by ChEMBL
LigandPNGBDBM50457451(BMS-908662 | EXEL-2819 | XL-281)
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of BRAF in human Jurkat T cells assessed as reduction in ERK phosphorylationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed