BDBM50391802 (3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone::CHEMBL2146883::COBIMETINIB FUMARATE::Cotellic::GDC-0973::XL518::cobimetinib

SMILES c1cc(c(cc1I)F)Nc2c(ccc(c2F)F)C(=O)N3CC(C3)([C@@H]4CCCCN4)O

InChI Key InChIKey=BSMCAPRUBJMWDF-UHFFFAOYSA-N

Data  105 IC50

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 105 hits for monomerid = 50391802   

LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.900nMAssay Description:Inhibition of MEK1-mediated ERK2 T202/Y204 phosphorylation using biotinylated MBP as substrate preincubated for 30 mins measured after 100 mins by cR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 0.900nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 4.20nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase ABL1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAC-beta serine/threonine-protein kinase(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetALK tyrosine kinase receptor(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase kinase kinase 5(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetAurora kinase A(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase B-raf(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetTyrosine-protein kinase BTK(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type II subunit alpha(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCalcium/calmodulin-dependent protein kinase type 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor alpha/beta(Mouse)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetCasein kinase II subunit alpha 3(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity protein kinase CLK3(Homo sapiens)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDeath-associated protein kinase 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEpidermal growth factor receptor(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase MARK2(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 2(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-A receptor 4(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetEphrin type-B receptor 4(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 3(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMitogen-activated protein kinase 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFocal adhesion kinase 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase Fes/Fps(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetFibroblast growth factor receptor 3(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetBeta-adrenergic receptor kinase 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetG protein-coupled receptor kinase 5(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetHomeodomain-interacting protein kinase 1(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Human)
Genentech, Inc and Exelixis

Curated by ChEMBL
LigandPNGBDBM50391802(CHEMBL2146883 | cobimetinib | (3,4-difluoro-2-(2-f...)
Affinity DataIC50: 1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/13/2025
Entry Details
PubMed
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