BDBM50250926 1-ethyl-6-((3-fluoro-5-(4-methoxytetrahydro-2H-pyran-4-yl)phenoxy)methyl)quinolin-2(1H)-one::CHEMBL459236::ZM-230487

SMILES CCn1c2ccc(COc3cc(F)cc(c3)C3(CCOCC3)OC)cc2ccc1=O

InChI Key InChIKey=ZROVOGSXAWNIQB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50250926   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50250926(ZM-230487 | 1-ethyl-6-((3-fluoro-5-(4-methoxytetra...)
Affinity DataIC50: 60nMAssay Description:Inhibitory concentration required against 5-lipoxygenase activity in intact cells of human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50250926(ZM-230487 | 1-ethyl-6-((3-fluoro-5-(4-methoxytetra...)
Affinity DataIC50: 90nMAssay Description:Inhibition of 5LO-mediated LTB4 production in human neutrophils by RIAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Human)
Universidad De Valencia

Curated by ChEMBL
LigandPNGBDBM50250926(ZM-230487 | 1-ethyl-6-((3-fluoro-5-(4-methoxytetra...)
Affinity DataIC50: 90nMAssay Description:Inhibitory concentration required against 5-lipoxygenase activity in cytosolic fractions of human neutrophilsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/28/2012
Entry Details Article
PubMed