BDBM50304148 1H-Indazol-5-ylamine::1H-indazol-5-amine::CHEMBL17551::US9409868, 8::cid_88012

SMILES c1cc2c(cc1N)cn[nH]2

InChI Key InChIKey=XBTOSRUBOXQWBO-UHFFFAOYSA-N

Data  6 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50304148   

TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.29E+4nMAssay Description:Source (MLSCN Center Name): The Scripps Research Institute Molecular Screening Center Center Affiliation: The Scripps Research Institute, TSRI Assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2011
Entry Details
PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataEC50:  4.86E+4nMAssay Description:Keywords: GFP, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, which interrupt the DnaB, RecA, a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetProtein RecA(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
Broad Institute

Curated by PubChem BioAssay
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataEC50:  3.61E+4nMAssay Description:Keywords: GFP-RecA intein, protein splicing, refolding, reducing reagent, GFP fluorescence Assay Overview: M. tuberculosis harbors three inteins, whi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2011
Entry Details
PCBioAssay
TargetRho-associated protein kinase 1 [1-535](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.81E+5nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetRho-associated protein kinase 2 [1-552](Human)
H. Lee Moffin Cancer Center and Research Institute

US Patent
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.20E+5nMpH: 7.5 T: 2°CAssay Description:A robust FRET-based, enzyme-coupled assay format, Z-Lyte® Kinase Assay Ser/Thr 13 Peptide Kit (Invitrogen, cat. PV3793), was employed in this stu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/24/2017
Entry Details
Go to US Patent

TargetNitric oxide synthase, brain(Human)
Uned

Curated by ChEMBL
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of recombinant NOS1 assessed as citrulline formationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2010
Entry Details Article
PubMed
TargetRho-associated protein kinase 1(Human)
H. Lee Moffitt Cancer Center and Research Institute

Curated by ChEMBL
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.81E+5nMAssay Description:Inhibition of human His-puritin-tagged ROCK1 expressed in Sf9 cells after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetRho-associated protein kinase 2(Human)
The Scripps Research Institute Molecular Screening Center

Curated by PubChem BioAssay
LigandPNGBDBM50304148(CHEMBL17551 | 1H-indazol-5-amine | cid_88012 | 1H-...)
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of ROCK2 after 1 hr by FRET-based enzyme-coupled assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed