BDBM50148071 (-)-N-(Cycloproylmethyl)-4,14-dimethoxymorphinan-6-one(Cyprodime)::17-cyclopropylmethyl-10-hydroxy-4,14-dimethoxy-(1S,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3-dien-6-one(cyprodime)::17-cyclopropylmethyl-3,10-dimethoxy-(1R,9R,10S)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-trien-13-one::CHEMBL322796::CYPRODIME BROMIDE::Naltrindole analogue::cyprodime

SMILES COc1cccc2C[C@H]3N(CC4CC4)CC[C@@]4(CC(=O)CC[C@@]34OC)c12

InChI Key InChIKey=INUCRGMCKDQKNA-UHFFFAOYSA-N

Data  13 KI  2 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 18 hits for monomerid = 50148071   

LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details Article
PubMed
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of [3H]naloxone binding to opioid receptor in presence of NaClMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2019
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataEC50:  117nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor kappa 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataEC50:  20nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human Opioid receptor mu 1 expre...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataEC50:  1.11E+3nMAssay Description:Concentration necessary to produce 50% of the Emax value, i.e. to stimulate [35S]GTP-gamma-S, binding to recombinant human opioid receptor delta 1 ex...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  11nMAssay Description:Binding affinity to mu opioid receptor (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  11nMAssay Description:Binding affinity against Opioid receptor mu 1 from rat brain membranes using [3H]DAMGOMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  24nMAssay Description:Binding affinity was evaluated by measuring the ability to displace [3H]DAMGO radioligand binding from Opioid receptor mu 1 in guinea pig brain membr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  24nMAssay Description:Binding affinity by its ability to displace [3H]DAMGO from mu receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  61nMAssay Description:In vivo binding affinity was evaluated by measuring the ability to displace [3H]DPDPE radioligand binding from delta opioid receptor in guinea pig br...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  61nMAssay Description:Binding affinity by its ability to displace [3H]-U-69,593 from kappa receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  105nMAssay Description:In vivo binding affinity was evaluated by measuring the ability to displace [3H]U-69593 radioligand binding from Opioid receptor kappa 1 in guinea pi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/30/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  105nMAssay Description:Binding affinity by its ability to displace [3H]DPDPE from delta receptor in homogenates of guinea pig brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2012
Entry Details Article

TargetKappa-type opioid receptor(Guinea pig)
TBA

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  110nMAssay Description:Binding affinity against Opioid receptor kappa 1 from guinea pig brain membranes using [3H]U-69593More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  417nMAssay Description:Binding affinity against Opioid receptor delta 1 from rat brain membranes using [3H]DADLEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2014
Entry Details Article
PubMed
TargetMu-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  1.06E+4nMAssay Description:Binding affinity determined by displacing [3H]DAMGO from Opioid receptor mu 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Medicine & Dentistry of New Jersey-Robert Wood Johnson Medical School (Umdnj-Rwjms)

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  4.14E+5nMAssay Description:Binding affinity determined by displacing [3H][Ile5,6]deltorphin II from opioid receptor delta 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Rat)
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50148071(Naltrindole analogue | 17-cyclopropylmethyl-3,10-d...)
Affinity DataKi:  1.09E+5nMAssay Description:Binding affinity determined by displacing [3H]U69,593 from Opioid receptor kappa 1 in rat brain membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed