BDBM10859 4-methylbenzene-1-sulfonamide::CHEMBL574::aromatic/heteroaromatic sulfonamide 4::hCA inhibitor, 7

SMILES Cc1ccc(cc1)S(=O)(=O)N

InChI Key InChIKey=LMYRWZFENFIFIT-UHFFFAOYSA-N

Data  89 KI  5 IC50  4 Kd  2 Koff

PDB links: 4 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 100 hits for monomerid = 10859   

TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKd:  2.93E+5nMAssay Description:Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as dissociation constant by SPR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 6(Human)
Ataturk University

LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataIC50: 1.90E+4nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataIC50: 715nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 1(Human)
Ataturk University

LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataIC50: 2.21E+4nMAssay Description:Carbonic anhydrase activity was assayed by following the change in absorbance at 348 nm of 4-nitrophenylacetate (NPA) to 4-nitrophenylate ion over a ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/17/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 5A, mitochondrial(Human)
Università

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataIC50: 4.70E+3nMAssay Description:Inhibitory concentration against human cystolic isozyme V of Carbonic anhydraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataIC50: 580nMAssay Description:Inhibitory concentration against human cystolic isozyme II of Carbonic anhydraseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKd:  3.32E+5nMAssay Description:Binding affinity to GST-fused human carbonic anhydrase-2 expressed in Escherichia coli BL21 codon plus cells assessed as steady state dissociation co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/22/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKon:  0.0600M-1s-1Assay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as dissociation rate consta...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKd:  0.130nMAssay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic thermodynamic ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKd:  430nMAssay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as thermodynamic equilibriu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKon:  0.0600M-1s-1Assay Description:Binding affinity to human full length His-tagged CA2 (1 to 260 residues) expressed in Escherichia coli BL21(DE3) assessed as intrinsic dissociation r...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/23/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 12(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  1.80nMAssay Description:Ki value against human carbonic anhydrase XII (hCA XII)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
The University of Tokushima Graduate School

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  58nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Bovine)
The University of Tokushima Graduate School

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  58nMAssay Description:Binding affinity to bovine carbonic anhydrase 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetCarbonic anhydrase 7(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  88nMAssay Description:Ki value against human carbonic anhydrase VIIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMed
TargetCarbonic anhydrase, alpha family(Thiomicrospira crunogena (strain XCL-2))
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  244nMAssay Description:Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Ki value against human carbonic anhydrase II (hCA II)More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMpH: 7.5Assay Description:Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMpH: 7.5Assay Description:Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2011
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/27/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/18/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant CA2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/6/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Ki value against human carbonic anhydrase IIMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/2/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human esterase activity of carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/24/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/26/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/19/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/4/2019
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/27/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nM ΔG°:  -8.85kcal/molepH: 7.5 T: 2°CAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/14/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/10/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/16/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/25/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCarbonic anhydrase 2(Human)
Istituto Italiano Di Tecnologia

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  320nMAssay Description:Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/12/2017
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDelta carbonic anhydrase(Thalassiosira weissflogii)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  424nMAssay Description:Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2014
Entry Details Article
PubMed
TargetCARBONIC ANHYDRASE(Helicobacter pylori (strain J99 / ATCC 700824) (Ca...)
Kochi Medical School

LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  450nMAssay Description:An Applied Photophysics stopped-flow instrument has been used for assaying the CA-catalyzed CO2 hydration activity. Phenol red has been used as indic...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 9(Human)
Kochi Medical School

Curated by ChEMBL
LigandPNGBDBM10859(CHEMBL574 | 4-methylbenzene-1-sulfonamide | aromat...)
Affinity DataKi:  460nMAssay Description:Inhibition of catalytic domain of human recombinant CA IXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
Displayed 1 to 50 (of 100 total ) | Next | Last >>