BDBM10995 (1R)-N-methyl-2,3-dihydro-1H-inden-1-amine::N-methyl-1(R)-aminoindan::R-MAI::rasagiline analog

SMILES CN[C@@H]1CCc2c1cccc2

InChI Key InChIKey=AIXUYZODYPPNAV-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 10995   

Target3-phosphoinositide-dependent protein kinase 1(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM10995((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine | N-met...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PDK1 (unknown origin) using PDKtide substrate and [gamma-32P]ATP by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
Target3-phosphoinositide-dependent protein kinase 1(Human)
La Trobe University

Curated by ChEMBL
LigandPNGBDBM10995((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine | N-met...)
Affinity DataIC50: 200nMAssay Description:Inhibition of PDK1 (unknown origin) expressed in HEK293 cells using PDKtide as substrate after 10 mins by liquid scintillation counting in presence o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2016
Entry Details Article
PubMed
TargetAmine oxidase [flavin-containing] B(Human)
University of Pavia

LigandPNGBDBM10995((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine | N-met...)
Affinity DataKi:  1.70E+4nM ΔG°:  -6.50kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAmine oxidase [flavin-containing] A(Human)
University of Pavia

LigandPNGBDBM10995((1R)-N-methyl-2,3-dihydro-1H-inden-1-amine | N-met...)
Affinity DataKi:  5.60E+4nM ΔG°:  -5.80kcal/molepH: 7.5 T: 2°CAssay Description:MAO A and MAO B activities were determined spectrophotometrically at 316 nm and 250 nm using kynuramine and benzylamine as substrates, respectively. ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/12/2006
Entry Details Article
PubMed