BDBM11343 (2S)-2-[benzyl(4-methoxybenzene)sulfonamido]-N-hydroxy-3-methylbutanamide::Hydroxamate 24::N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydroxamate

SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1ccccc1)[C@@H](C(C)C)C(=O)NO

InChI Key InChIKey=ZGSTVUAZFACDLH-UHFFFAOYSA-N

Data  10 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 11343   

TargetMacrophage metalloelastase(Mouse)
Novartis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataIC50: 16nMAssay Description:Inhibitory activity against mouse macrophage metalloelastase (MME) using [3H]elastin as a substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataIC50: 43nMAssay Description:Inhibition of MMP1More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  11nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  11nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetNeutrophil collagenase(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  13nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCollagenase ColG(Hathewaya histolytica)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  17nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  27nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  27nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/23/2013
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Pomona College

Curated by ChEMBL
LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  43nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 4(Bovine)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi:  185nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi

LigandPNGBDBM11343(N-4-Methoxyphenylsulfonyl-N-benzyl-L-valine hydrox...)
Affinity DataKi: >200nMAssay Description:Initial rates of 4-nitrophenyl acetate hydrolysis catalyzed by different CA isozymes were monitored spectrophotometrically at 400 nm. A molar absorpt...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/2/2006
Entry Details Article
PubMed