BDBM14169 4-Iodobenzo[b]thiophene-2-carboxamidine::APC-6860::CA-01::CRA-6860::[amino(4-iodo-1-benzothiophen-2-yl)methylidene]azanium

SMILES c1cc2c(cc(s2)C(=[NH2+])N)c(c1)I

InChI Key InChIKey=YERQOXAYAFWFEJ-UHFFFAOYSA-O

Data  8 KI

PDB links: 6 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14169   

TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  210nM ΔG°:  -9.01kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetUrokinase-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  250nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine protease 1(Bovine)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  440nM ΔG°:  -8.58kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetTryptase beta-2(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  1.50E+3nM ΔG°:  -7.86kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  1.70E+3nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetTissue-type plasminogen activator(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  1.68E+4nM ΔG°:  -6.44kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  2.00E+4nM ΔG°:  -6.34kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCoagulation factor X(Human)
Axys Pharmaceutical

LigandPNGBDBM14169(CA-01 | [amino(4-iodo-1-benzothiophen-2-yl)methyli...)
Affinity DataKi:  3.00E+4nM ΔG°:  -6.10kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/6/2007
Entry Details Article
PubMed