BDBM15246 1-(5-Chloro-2-methoxyphenyl)-3-[6-[1-(dimethylamino)propan-::3-(5-chloro-2-methoxyphenyl)-1-(6-{[1-(dimethylamino)propan-2-yl]oxy}pyrazin-2-yl)urea::macrocyclic inhibitor 4

SMILES C[C@@H](CN(C)C)Oc1cncc(n1)NC(=O)Nc2cc(ccc2OC)Cl

InChI Key InChIKey=GIAYFZLMPSVQDV-UHFFFAOYSA-N

Data  1 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 15246   

TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

LigandPNGBDBM15246(3-(5-chloro-2-methoxyphenyl)-1-(6-{[1-(dimethylami...)
Affinity DataIC50: 22nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/7/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetSerine/threonine-protein kinase Chk1(Human)
Abbott Laboratories

LigandPNGBDBM15246(3-(5-chloro-2-methoxyphenyl)-1-(6-{[1-(dimethylami...)
Affinity DataKi:  20nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/21/2013
Entry Details Article
PubMedPDB3D3D Structure (crystal)