BDBM18045 5-(PHENYLSULFANYL)-2,4-QUINAZOLINEDIAMINE::5-(phenylsulfanyl)quinazoline-2,4-diamine::GW997

SMILES c1ccc(cc1)Sc2cccc3c2c(nc(n3)N)N

InChI Key InChIKey=BUFDQCGCADQQQY-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18045   

TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18045(5-(phenylsulfanyl)quinazoline-2,4-diamine | 5-(PHE...)
Affinity DataIC50: 34nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18045(5-(phenylsulfanyl)quinazoline-2,4-diamine | 5-(PHE...)
Affinity DataIC50: 620nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed