BDBM18048 5-{[4-(4-MORPHOLINYL)PHENYL]SULFANYL}-2,4-QUINAZOLINEDIAMIN::5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-2,4-diamine::GW2021

SMILES c1cc2c(c(c1)Sc3ccc(cc3)N4CCOCC4)c(nc(n2)N)N

InChI Key InChIKey=CZLWCJRHDBTCGQ-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 18048   

TargetDihydrofolate reductase(Yeast)
Gsk

LigandPNGBDBM18048(5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-...)
Affinity DataIC50: 130nMpH: 6.4 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetDihydrofolate reductase(Human)
Gsk

LigandPNGBDBM18048(5-{[4-(morpholin-4-yl)phenyl]sulfanyl}quinazoline-...)
Affinity DataIC50: 7.00E+4nMpH: 7.0 T: 2°CAssay Description:IC50 is the concentration of inhibitor that decreases the velocity of the standard assay by 50%. The enzyme, NADPH, and varying concentrations of inh...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/30/2007
Entry Details Article
PubMed