BDBM181109 3-Mercaptopicolinic acid (MPA)

SMILES c1cc(c(nc1)C(=O)O)S

InChI Key InChIKey=ZYFDNIOIEFZULT-UHFFFAOYSA-N

Data  6 KI

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 181109   

TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  3.70E+4nM ΔG°:  -6.04kcal/moleT: 2°CAssay Description:OAA/PEP binding site. When the enzyme was assayed in the direction of PEP →OAA, the standard reaction mixture contained 50 mM HEPES (pH 7.5), 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  4.50E+4nM ΔG°:  -5.93kcal/moleT: 2°CAssay Description:OAA/PEP binding site. The activity of PEPCK in the direction from OAA to PEP was assayed with 50 mM HEPES (pH 7.5), 10 mM DTT, 4 mM MgCl2, 0.5 mM GTP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  8.30E+4nM ΔG°:  -5.56kcal/moleT: 2°CAssay Description:Allosteric binding site. When the enzyme was assayed in the direction of PEP →OAA, the standard reaction mixture contained 50 mM HEPES (pH 7.5)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  8.30E+4nM ΔG°:  -5.56kcal/moleT: 2°CAssay Description:OAA/PEP binding site. When the enzyme was assayed in the direction of PEP →OAA, the standard reaction mixture contained 50 mM HEPES (pH 7.5), 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  1.21E+5nM ΔG°:  -5.34kcal/moleT: 2°CAssay Description:Allosteric binding site. The activity of PEPCK in the direction from OAA to PEP was assayed with 50 mM HEPES (pH 7.5), 10 mM DTT, 4 mM MgCl2, 0.5 mM ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Rat)
The University of Kansas Medical Center

LigandPNGBDBM181109(3-Mercaptopicolinic acid (MPA))
Affinity DataKi:  1.80E+5nM ΔG°:  -5.11kcal/moleT: 2°CAssay Description:Allosteric binding site. When the enzyme was assayed in the direction of PEP →OAA, the standard reaction mixture contained 50 mM HEPES (pH 7.5)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/2/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)