BDBM20609 1-(4-{octahydro-1H-pyrido[1,2-a]piperazin-2-yl}phenyl)-2-phenyl-1,2,3,4-tetrahydroisoquinolin-6-ol::Piperazine Derivative, 29

SMILES c1ccc(cc1)[N@@]2CCc3cc(ccc3[C@H]2c4ccc(cc4)[N@]5CC[N@@]6CCCC[C@H]6C5)O

InChI Key InChIKey=ZGHFWBDHZZKWSI-UHFFFAOYSA-N

Data  2 IC50  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20609   

TargetEstrogen receptor(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20609(1-(4-{octahydro-1H-pyrido[1,2-a]piperazin-2-yl}phe...)
Affinity DataIC50: 63nM EC50:  23.2nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetEstrogen receptor beta(Human)
Novartis Pharmaceuticals

LigandPNGBDBM20609(1-(4-{octahydro-1H-pyrido[1,2-a]piperazin-2-yl}phe...)
Affinity DataIC50: 252nM EC50:  98nMpH: 7.4 T: 2°CAssay Description:Radioligand binding assay was performed by using 96-well microtiterplates containing ER, 17beta-estradiol, and the test compound to be tested and SPA...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/16/2008
Entry Details Article
PubMed