BDBM21692 1-(4-chlorophenyl)-3-[1-methyl-3-oxo-2-phenyl-5-(propan-2-yl)-2,3-dihydro-1H-pyrazol-4-yl]urea::1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl]urea::CHEMBL379761::Pyrazolone, 1

SMILES CC(C)C1=C(C(=O)N(N1C)c2ccccc2)NC(=O)Nc3ccc(cc3)Cl

InChI Key InChIKey=PAEBEUZTAPIOIO-UHFFFAOYSA-N

Data  6 EC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 21692   

TargetN-formyl peptide receptor 2(Human)
Amgen

LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  44nMpH: 7.2 T: 2°CAssay Description:hFPRL 1 activity was assayed using an aequorin-based bioluminescence assay (Ca2+ flux). EC50 values have been determined by Ca2+ flux in CHO recombin...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/29/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN-formyl peptide receptor 2(Human)
Amgen

LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  44nMAssay Description:Activity at human FPRL1-mediated calcium mobilization in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetN-formyl peptide receptor 2(Human)
Amgen

LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  95nMAssay Description:Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetfMet-Leu-Phe receptor(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  51nMAssay Description:Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphasc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
TargetN-formyl peptide receptor 2(Human)
Amgen

LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  41nMAssay Description:Biased agonist activity at human FPR2 expressed in FlpIn-CHO cells assessed as stimulation of ERK1/2 phosphorylation measured after 7 mins by Alphasc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetfMet-Leu-Phe receptor(Human)
Monash University

Curated by ChEMBL
LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  32nMAssay Description:Biased agonist activity at human FPR1 expressed in FlpIn-CHO cells assessed as intracellular calcium mobilization by Fluo-4-AM dye based fluorescence...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2021
Entry Details Article
PubMed
LigandPNGBDBM21692(1-(4-chlorophenyl)-3-[1-methyl-5-(1-methylethyl)-3...)
Affinity DataEC50:  890nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details