BDBM220190 US9290476, 33A::US9290476, 33B::US9290476, 33C

SMILES COc1nc2ccc(cc2c(Cl)c1Cc1ccc(cc1)-n1cccn1)C(O)(c1cncn1C)c1ccc(Cl)cc1

InChI Key InChIKey=UWOBQISTECYGOP-UHFFFAOYSA-N

Data  5 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 220190   

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  43nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  810nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetIsoform 2 of Nuclear receptor ROR-gamma (RORgT)(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  20nMpH: 7.0 T: 2°CAssay Description:Bar-coded assay plates are robotically loaded onto a thermostatically controlled PCR-type thermal block and then heated at a typical ramp-rate of 1 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/3/2017
Entry Details
Go to US Patent

TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataIC50: 73nMAssay Description:Inverse agonist activity at GAL4 DBD-fused human RORgammat expressed in HEK293T cells assessed as inhibition of transcriptional activity after 24 hrs...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  9.20nMAssay Description:Displacement of 1,8-ANS from recombinant human RORgammat LBD expressed in Escherichia coli BL21 (DE3) cells assessed as inhibition of co-activator SR...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataIC50: 85nMAssay Description:Inverse agonist activity at RORgammat in human Th17 cells assessed as inhibition of IL17A productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/18/2019
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  9.20nMAssay Description:Displacement of 1,8-ANS from human N-terminal His-tagged RORgammat LBD (850 to 1635 residues) expressed in Escherichia coli by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataIC50: 73nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataIC50: 73nMAssay Description:Inverse agonist activity at GAL4 DBD-fused wild type human RORgammat LBD (850 to 1635 residues) expressed in HEK293T cells assessed as inhibition of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataKd:  9.20nMAssay Description:Displacement of 1,8-ANS from human N-terminal His-tagged RORgammat LBD (850 to 1635 residues) expressed in Escherichia coli by thermofluor assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/15/2020
Entry Details Article
PubMed
TargetNuclear receptor ROR-gamma(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33C | US9290476, 33B | US9290476, 33A)
Affinity DataIC50: 95nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed