BDBM225085 US9321756, 54

SMILES CC(C)(C)Nc1nnc(o1)-c1ccc2[nH]cc(-c3nccc(n3)C3CC3)c2c1

InChI Key InChIKey=BQKBRLMFCCUJQA-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 225085   

TargetSerine/threonine-protein kinase pim-2(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM225085(US9321756, 54)
Affinity DataKi:  0.280nMAssay Description:Binding affinity to PIM2 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM225085(US9321756, 54)
Affinity DataKi:  0.550nMAssay Description:Binding affinity to PIM1 (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/12/2025
Entry Details
PubMed
TargetSerine/threonine-protein kinase pim-1(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM225085(US9321756, 54)
Affinity DataIC50: 1.58nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
US Patent

TargetSerine/threonine-protein kinase pim-2(Human)
Joint Research Institution of Altitude Health and Institute of Respiratory Health and National Clinical Research Center for Geriatrics

Curated by ChEMBL
LigandPNGBDBM225085(US9321756, 54)
Affinity DataIC50: 2.40nMAssay Description:The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/8/2017
Entry Details
US Patent