BDBM23771 (3-{[1-benzyl-3-(carbamoylmethyl)-2-ethyl-1H-indol-5-yl]oxy}propyl)phosphonic acid::CHEMBL146186::LY311727

SMILES CCc1c(c2cc(ccc2n1Cc3ccccc3)OCCCP(=O)(O)O)CC(=O)N

InChI Key InChIKey=OPWQYOUZRHDKBR-UHFFFAOYSA-N

Data  9 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 23771   

TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 470nMpH: 7.5 T: 2°CAssay Description:PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase A2, major isoenzyme(Pig)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 8.00E+3nMAssay Description:PLA2 activity is by using the fluorescent phospholipid analogue, beta-pyC-10-PG as the substrate. The increase in fluorescence (ex @342 nm and em@388...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/25/2008
Entry Details Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibitory activity against porcine pancreatic Phospholipase A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 9.11E+4nMAssay Description:Inhibitory activity against human pancreatic Phospholipase A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 23nMAssay Description:Inhibition of human non-pancreatic secretory phospholipase A2 (PLA2) in a chromogenic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase A2, major isoenzyme(Pig)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of pig group IB PLA2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human group IIA PLA2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPhospholipase A2, major isoenzyme(Pig)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of porcine group 1B phospholipase A2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetPhospholipase A2, membrane associated(Human)
Universite Paris 7-Denis Diderot

LigandPNGBDBM23771(CHEMBL146186 | (3-{[1-benzyl-3-(carbamoylmethyl)-2...)
Affinity DataIC50: 470nMAssay Description:Inhibition of human recombinant group 2A phospholipase A2 by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)