BDBM243470 US9427440, 18

SMILES COc1ccc2-c3c(C4CCCCC4)c4ccc5cc4n3CC(=Cc2c1)C(=O)N(C)CCCCN(C)S(=O)(=O)NC5=O

InChI Key InChIKey=LTHKMHZATSPXJT-UHFFFAOYSA-N

Data  1 IC50  1 Kd  1 EC50  1 Koff  1 Kon

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 243470   

TargetGenome polyprotein [1027-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243470(US9427440, 18)
Affinity DataEC50:  79nMAssay Description:The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetGenome polyprotein [2420-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243470(US9427440, 18)
Affinity DataIC50: 26nMT: 2°CAssay Description:IC50 con1b were determined according to the method as described previously (Pauwels et al, 2007, J Virol 81:6909-19) using a primer-dependent transcr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
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TargetGenome polyprotein [2420-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243470(US9427440, 18)
Affinity DataKd:  2.40nMpH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent

TargetGenome polyprotein [2420-3010](HCV)
Janssen Ireland

US Patent
LigandPNGBDBM243470(US9427440, 18)
Affinity DataKon:  0.0000480M-1s-1 Koff:  2.00E+4s-1pH: 7.4 T: 2°CAssay Description:All measurements were performed on a Biacore T100 instrument (GE Healthcare). The purified HIS6-tagged NS5BΔC21 polymerases were immobilized us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2017
Entry Details
Go to US Patent