BDBM24768 5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophenyl}-2-[(4-fluorophenyl)amino]-3-methyl-3,4-dihydropyrimidin-4-one::pyrimidone, 50

SMILES CN1C(=O)C(=CN=C1Nc2ccc(cc2)F)c3ccc(c(c3)F)Oc4ccnc5c4cc(c(c5)OC)OC

InChI Key InChIKey=DUTNABYDBFVZOA-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 24768   

TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24768(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataIC50: 14nMAssay Description:Inhibition of human c-METMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetHepatocyte growth factor receptor(Human)
Sichuan University

Curated by ChEMBL
LigandPNGBDBM24768(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataKi:  14nM ΔG°:  -10.6kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2008
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM24768(5-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...)
Affinity DataKi:  382nM ΔG°:  -8.66kcal/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2008
Entry Details Article
PubMed