BDBM26133 (4-methoxyphenyl)boranediol::CHEMBL21427::Phenylboronic Acid, 12

SMILES COc1ccc(cc1)B(O)O

InChI Key InChIKey=VOAAEKKFGLPLLU-UHFFFAOYSA-N

Data  9 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 26133   

TargetFatty-acid amide hydrolase 1 [30-579](Rat)
University of Oxford

LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataIC50: 2.00E+3nMpH: 7.4 T: 2°CAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetMonoglyceride lipase(Human)
University of Oxford

LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataAssay Description:[3H]Ethanolamine produced from [3H]AEA hydrolysis was used to calculate FAAH activity and was measured by scintillation counting of the aqueous phase...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/17/2008
Entry Details Article
PubMed
TargetAutotaxin(Human)
Takeda California

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of full length human C-terminal 6-His-tagged ATXbeta using FS-3 as substrate preincubated for 20 mins followed by substrate addition by fl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/22/2020
Entry Details Article
PubMed
TargetBeta-lactamase(Escherichia coli (strain K12))
Northwestern University Medical School

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  5.90E+3nMAssay Description:Inhibitory activity against Escherichia coli AmpC beta-lactamase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCarbonic anhydrase 2(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  7.90E+3nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase 1(Human)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  1.09E+4nMAssay Description:Inhibition of human recombinant cytosolic carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetCarbonic anhydrase(Yeast)
Universita Degli Studi Di Firenze

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  1.56E+4nMAssay Description:Inhibition of Candida albicans recombinant Carbonic anhydrase pre-incubated for 15 mins by CO2 hydration stopped-flow assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMed
TargetBeta-lactamase TEM(Escherichia coli)
TBA

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  6.70E+5nMAssay Description:Inhibitory constant was determined against class A RTEM-1 Beta-lactamase from Escherichia coliMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2010
Entry Details Article

TargetSubtilisin BL(Bacillus lentus)
TBA

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  7.57E+5nMAssay Description:Competitive inhibition of Subtilisin BL M222C-mutated enzyme from Bacillus lentusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubtilisin Carlsberg(Bacillus licheniformis)
TBA

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  1.80E+5nMAssay Description:Competitive inhibition of Subtilisin Carlsberg enzyme from Bacillus lentusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubtilisin BL(Bacillus lentus)
TBA

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  3.10E+5nMAssay Description:Competitive inhibition of Subtilisin BL M222S-mutated enzyme from Bacillus lentusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article

TargetSubtilisin BL(Bacillus lentus)
TBA

Curated by ChEMBL
LigandPNGBDBM26133(CHEMBL21427 | (4-methoxyphenyl)boranediol | Phenyl...)
Affinity DataKi:  5.77E+5nMAssay Description:Competitive inhibition of Subtilisin BL wild type enzyme from Bacillus lentusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2010
Entry Details Article