BDBM26382 4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]-3-N-(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-5-yl)benzene-1,3-dicarboxamide::Aminopyrimidine amide, 19

SMILES Cc1ccc(cc1C(=O)Nc2cnc(nc2)Nc3ccc(cc3)N4CCN(CC4)C)NC(=O)c5cccc(c5C)C(F)(F)F

InChI Key InChIKey=YNJXLRWECIJSPA-UHFFFAOYSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 26382   

TargetTyrosine-protein kinase Lck(Human)
Amgen

LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 0.800nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAngiopoietin-1 receptor(Human)
Amgen

LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 8.30E+3nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 54nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 12nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed
LigandPNGBDBM26382(4-methyl-1-N-[2-methyl-3-(trifluoromethyl)benzene]...)
Affinity DataIC50: 2.50E+4nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2009
Entry Details Article
PubMed