BDBM264177 (2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2-[(3-methoxy-1- methyl-1H-pyrazol-4- yl)amino]pyrimidin-4-yl}- 1H-indol-7-yl)propanamide::US10167276, Example 1::US10654835, Example 1::US11247983, Example 1::US9714236, 1

SMILES COc1nn(C)cc1Nc1nccc(n1)-c1c[nH]c2c(NC(=O)[C@@H](C)N3CCN(C)C[C@@H]3C)cccc12

InChI Key InChIKey=UAKGPERAUAMZPO-UHFFFAOYSA-N

Data  16 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 264177   

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 847nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

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UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/15/2018
Entry Details
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TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMpH: 7.3Assay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
11/15/2018
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 847nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/24/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase JAK2 [808-1132](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/24/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase JAK3 [811-1124](Human)
Dizal (Jiangsu) Pharmaceutical

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
4/24/2019
Entry Details
Copy Entry DOIGo to US Patent

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TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 643nMAssay Description:Inhibition of JAK1 in human NCI-H1975 cells assessed as reduction in STAT3 phosphorylation incubated for 2 hrsMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/18/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetTyrosine-protein kinase JAK3(Human)
Therachem Research Medilab (India)

Curated by ChEMBL

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK3 (781 to 1124 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/18/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase JAK1(Human)
Therachem Research Medilab (India)

Curated by ChEMBL

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 847nMAssay Description:Inhibition of N-terminal GST fused human recombinant JAK1 (866 to 1154 amino acids) expressed in insect cells using ATP and peptide substrate (FITC-C...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/18/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase JAK2(Human)
Therachem Research Medilab (India)

Curated by ChEMBL

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of N-terminal GST fused recombinant JAK2 (831 to 1132 amino acids) (unknown origin) expressed in insect cells using ATP and peptide substr...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/18/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 847nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/1/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/1/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, PV4774, Carlsbad, Calif.), JAK2 (amino acid...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
2/1/2021
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase JAK1 [866-1154](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 847nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase JAK2 [831-1132](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL

TargetTyrosine-protein kinase JAK3 [781-1124](Human)
Astrazeneca

US Patent

LigandBDBM264177((2R)-2-[(2S)-2,4- dimethylpiperazin-1- yl]-N-(3-{2...)Copy SMILESCopy InChI

Affinity DataIC50: 3.00E+4nMAssay Description:Enzyme inhibition studies were performed using recombinant JAK1 (amino acids 866-1154, Life Technologies, #PV4774, Carlsbad, Calif.), JAK2 (amino aci...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/13/2022
Entry Details
Copy Entry DOIGo to US Patent

Copy Rxn URL