BDBM269585 (1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-pyridinyl)-4H-1,2,4-triazol-3-yl)-1-hydroxy-1-(5-methyl-2-pyrimidinyl)-2-propanesulfonamide::US10058550, Example 99.0::US10221162, Example 99.0::US9845310, Example 99.0

SMILES COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@@H](C)[C@H](O)c2ncc(C)cn2)nnc1-c1cccc(C)n1

InChI Key InChIKey=HNGYVRSMVVCWGF-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 269585   

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269585((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)
Affinity DataEC50:  2.30nMpH: 7.5Assay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/11/2018
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269585((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)
Affinity DataEC50:  2.30nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV -3 expression vector (Si...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

TargetApelin receptor(Human)
Amgen

US Patent
LigandPNGBDBM269585((1R,2S)-N-(4-(2,6-dimethoxyphenyl)-5-(6-methyl-2-p...)
Affinity DataEC50:  2.30nMAssay Description:The human APJ receptor was cloned by polymerase chain reaction and the gene encoding the receptor was subcloned in pFLAG-CMV-3 expression vector (Sig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/14/2019
Entry Details
Go to US Patent