BDBM429328 ALP-POS-c59291d4-6::CVD-0006355::US20240083885, Compound Jun8-48-1::jm5b01461, Compound 146

SMILES CC(C)(C)NC(=O)C(N(C(=O)c1ccco1)c1ccc(cc1)C(C)(C)C)c1cccnc1

InChI Key InChIKey=JXGIYKRRPGCLFV-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 429328   

TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 4.89E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(SARS-CoV)
University of Bonn

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 4.89E+3nMAssay Description:This is a review article.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/7/2020
Entry Details Article
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 3.14E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetSerine protease 1(Human)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 9.90E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/5/2021
Entry Details Article

TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 3.14E+3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of SARS-CoV-2 main protease incubated for 30 mins by FRET based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 1.10E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 -Mpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 6.00E+4nMAssay Description:Non-covalent inhibition of SARS-Cov-2 PLpro incubated for 30 mins using FRET substrate measured for 1 hr by FRET-based enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed
TargetReplicase polyprotein 1a(2019-nCoV)
Arizona Board Of Regents On Behalf Of The University Of Arizona

US Patent
LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataIC50: 11nMAssay Description:The main protease (Mpro) enzymatic assays were carried out exact as previously described in pH 6.5 reaction buffer containing 20 mM HEPES pH 6.5, 120...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/30/2024
Entry Details
Go to US Patent

TargetReplicase polyprotein 1ab(2019-nCoV)
Israel Institution of Biological Research

LigandPNGBDBM429328(jm5b01461, Compound 146 | ALP-POS-c59291d4-6 | CVD...)
Affinity DataKi:  70nMAssay Description:Non-covalent inhibition to SARS-CoV-2 -Mpro assessed as inhibition constant by native mass spectrometric analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/24/2023
Entry Details
PubMed