BDBM50005478 2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-ethyl]-phenol::2-methoxy-5-(3,4,5-trimethoxyphenethyl)phenol::CHEMBL10557

SMILES COc1ccc(cc1O)CCc2cc(c(c(c2)OC)OC)OC

InChI Key InChIKey=UXDFUVFNIAJEGM-UHFFFAOYSA-N

Data  7 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50005478   

TargetTubulin beta-2B chain(Bovine)
School of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 630nMAssay Description:Inhibition of tubulin polymerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 1.40E+3nMAssay Description:In vitro inhibition of purified bovine brain tubulin polymerisation in the absence of microtubule-associated proteins.More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/16/2018
Entry Details

LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 3.50E+3nMAssay Description:Concentration required to inhibit the extent of glutamate-dependent tubulin polymerization by 50% at 37 degrees C(1.0 mM MgCl2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of glutamate-dependent tubulin polymerization at 30 degrees C(0.25 mM MgCl2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/24/2019
Entry Details Article
PubMed
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 3.30E+3nMAssay Description:Ability to inhibit Tubulin polymerization in Bovine brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2019
Entry Details Article
PubMed
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 630nMAssay Description:Inhibition of bovine tubulin polymerizationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/21/2020
Entry Details Article
PubMed
TargetSortase family protein(Staphylococcus aureus)
Indian Institute of Technology Delhi

Curated by ChEMBL
LigandPNGBDBM50005478(CHEMBL10557 | 2-methoxy-5-(3,4,5-trimethoxypheneth...)
Affinity DataIC50: 6.57E+4nMAssay Description:Inhibition of wild type recombinant Staphylococcus aureus ATCC 25904 Sortase A expressed in Escherichia coli BL21 using Dabcyl-QALPETGEE-Edans as sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed