BDBM50012647 CHEMBL2396989

SMILES c1cc(c(cc1NC(=O)c2ccc(cn2)F)[C@]34COC[C@H]3CSC(=N4)N)F

InChI Key InChIKey=NIDRNVHMMDAAIK-UHFFFAOYSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50012647   

TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 20nMAssay Description:Inhibition of Fc domain of IgG1-fused human BACE1 (1 to 460) expressed in HEK293 cells preincubated for 10 mins followed by enzyme addition measured ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant BACE1 by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/10/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBeta-secretase 2(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetCathepsin D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/12/2021
Entry Details Article
PubMed
TargetBeta-secretase 1(Human)
Janssen Pharmaceutica

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human BACE1 using (MCA)-S-E-V-N-L-D-A-E-F-R-K(dinitrophenol)-R-R-R-R-NH2 as substrate incubated for 8 hrs by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetCathepsin D(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human Cathepsin D by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMed
TargetBeta-secretase 1(Mouse)
Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1 in mouse primary cortical neuron assessed as reduction in Amyloid-beta level incubated for 24 hrs by sandwich ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details Article
PubMedPDB3D3D Structure (crystal)