BDBM50015314 CHEMBL3263869

SMILES COc1ccc(Oc2cc(C)c(-c3csc(NC(=O)c4ccnc(F)c4)n3)c(C)c2)cc1

InChI Key InChIKey=JZGFZITYBNEDHQ-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50015314   

TargetMast/stem cell growth factor receptor Kit(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Kit (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K alpha (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of mTOR (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora B (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora A (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Cdk1/cyclin B (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk2(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of CHK1 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Nek2(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Nek2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [3H]astemizole from human ERG after 60 mins by competitive binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3K beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MET (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of C-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of B-Raf (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of IGF-1R (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PDGFR-beta (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Development Center For Biotechnology

Curated by ChEMBL
LigandPNGBDBM50015314(CHEMBL3263869)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin) assessed as [33P] incorporation in substrate by TopCount microplate scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/9/2015
Entry Details Article
PubMed