BDBM50017964 CHEMBL3289656

SMILES C(CN1CCN(CC1)c1ncccn1)Cc1nc2ccccc2s1

InChI Key InChIKey=PQVQCEDGSJVHMK-UHFFFAOYSA-N

Data  15 KI  5 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 24 hits for monomerid = 50017964   

TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataIC50: 72nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataIC50: 1.51E+4nMAssay Description:Antagonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataEC50:  2.34E+3nMAssay Description:Agonist activity at human D3 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataIC50: 1.02E+4nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-ga...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataEC50:  1.06E+3nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as beta arrestin recruitment preincubated for 90 mins by tropix-gal s...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataIC50: 32nMAssay Description:Antagonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataEC50:  4.30nMAssay Description:Agonist activity at human D4 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataEC50:  1.18E+6nMAssay Description:Agonist activity at human D2 receptor stably expressed in CHO-K1 cells assessed as inhibition of forskolin stimulated cAMP production incubated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetD(4) dopamine receptor(Rat)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]N-methylspiperone from rat dopamine D4 receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(4) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  6.5nMAssay Description:Displacement of [3H]N-methylspiperone from human D4 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5-HT1A receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  47nMAssay Description:Displacement of [3H]LSD from human 5-HT2B receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-2C adrenergic receptor(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]clonidine from human adrenergic-alpha2C receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  259nMAssay Description:Displacement of [3H]prazosin from human adrenergic-alpha1A receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Rat)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  280nMAssay Description:Displacement of [3H]mesulergine from rat 5-HT2C receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Rat)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  283nMAssay Description:Displacement of [3H]ketanserin from rat 5-HT2A receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 7(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  342nMAssay Description:Displacement of [3H]LSD from human 5-HT7 receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetSigma non-opioid intracellular receptor 1(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  350nMAssay Description:Binding affinity to sigma-1 receptor (unknown origin) by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  730nMAssay Description:Displacement of [3H]pyrilamine from human histamine H1 receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetAlpha-2A adrenergic receptor(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  844nMAssay Description:Displacement of [3H]clonidine from human adrenergic-alpha2A receptor by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  1.65E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Florida A&M University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  2.77E+3nMAssay Description:Displacement of [3H]nisoxetine from human NET by PDSP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
High Point University

Curated by ChEMBL
LigandPNGBDBM50017964(CHEMBL3289656)
Affinity DataKi:  6.37E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor stably expressed in HEK293 cell membrane assessed as inhibition constant incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2024
Entry Details
PubMed