BDBM50017994 CHEMBL3289658

SMILES Cc1ccc\2c(c1)CCC/C2=C\C(=C/C=C/C(=C/C(=O)O)/C)\C

InChI Key InChIKey=KHXSEEGTXMJURJ-UHFFFAOYSA-N

Data  2 Kd  2 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50017994   

TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50017994(CHEMBL3289658)
Affinity DataKd:  1.75E+3nMAssay Description:Agonist activity at human RXR-alpha-ligand binding domain homodimers assessed as coactivator recruitment by measuring GRIP1 binding to receptor by is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50017994(CHEMBL3289658)
Affinity DataKd:  15nMAssay Description:Binding affinity to human RXR-alpha-ligand binding domain homodimers by fluorescence quenching methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Human)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50017994(CHEMBL3289658)
Affinity DataEC50:  100nMAssay Description:Agonist activity at Gal4-fused human RXR-alpha expressed in HEK293 cells assessed as receptor-mediated transcriptional activity treated 24 hrs after ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRetinoic acid receptor RXR-alpha(Rat)
University of Alabama At Birmingham

Curated by ChEMBL
LigandPNGBDBM50017994(CHEMBL3289658)
Affinity DataEC50:  110nMAssay Description:Agonist activity at RXR-alpha in rat R3KE cells infected with oncogene KLF4-ER assessed as inhibition of KLF4-mediated oncogenic transformationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2015
Entry Details Article
PubMedPDB3D3D Structure (crystal)