BDBM50027431 HYDROXYFASUDIL::Hydroxy-Fasudil

SMILES c1cc2c(ccnc2O)c(c1)S(=O)(=O)[N@]3CCCNCC3

InChI Key InChIKey=ZAVGJDAFCZAWSZ-UHFFFAOYSA-N

Data  2 KI  6 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50027431   

TargetPoly [ADP-ribose] polymerase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 800nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 600nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 194nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human ROCK2 (5 to 554 residues) expressed in baculovirus infected Sf9 cells using S6K as substrate in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/22/2023
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 720nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 2(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataIC50: 720nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/19/2024
Entry Details
PubMed
TargetRho-associated protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataKi:  150nMAssay Description:Inhibition of human ROCK1 by homogenous luciferase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/28/2012
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetRho-associated protein kinase 1(Human)
West China Hospital

Curated by ChEMBL
LigandPNGBDBM50027431(Hydroxy-Fasudil | HYDROXYFASUDIL)
Affinity DataKi:  150nMAssay Description:Inhibition of human leukocytic ROCK1 expressed in insect cells using KKRNRTLSV as substrate after 10 mins by pyruvate kinase/lactate dehydrogenase co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/21/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)