BDBM50048389 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine::4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cyclohepta[f]inden-5-yl)-phenylamine (GYKI 52466)::CHEMBL275006::GYKI-52466

SMILES CC1=NN=C(c2cc3c(cc2C1)OCO3)c4ccc(cc4)N

InChI Key InChIKey=LFBZZHVSGAHQPP-UHFFFAOYSA-N

Data  6 KI

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50048389   

TargetGlutamate receptor 2(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi:  4.00E+3nMAssay Description:Antagonist activity at closed state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 2(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi:  5.00E+3nMAssay Description:Antagonist activity at open state of GFP-tagged GluA2Qflip isoform (unknown origin) expressed in HEK293S cells assessed as reduction in glutamate-ind...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlutamate receptor 3(Human)
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
TargetGlutamate receptor 3(Human)
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
TargetGlutamate receptor 3(Rat)
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details
PubMed
TargetGlutamate receptor 3(Rat)
Sibia Neurosciences

Curated by PDSP Ki Database
LigandPNGBDBM50048389(GYKI-52466 | 4-(8-Methyl-9H-1,3-dioxa-6,7-diaza-cy...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/24/2012
Entry Details Article
PubMed