BDBM50050533 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL::6-Benzyl-1-benzyloxymethyl-5-isopropyl-1H-pyrimidine-2,4-dione::6-benzyl-1-(benzyloxymethyl)-5-isopropyluracil::CHEMBL436546::TNK-651

SMILES CC(C)C1=C(N(C(=O)NC1=O)COCc2ccccc2)Cc3ccccc3

InChI Key InChIKey=KSAAUHMSLCPIEX-UHFFFAOYSA-N

Data  6 IC50

PDB links: 3 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50050533   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Oxford University

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against HIV-1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetIntegrase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HIV1 integrase expressed in Escherichia coli BL21 (DE3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMed
TargetReverse transcriptase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 16nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 40nMAssay Description:Inhibition of HIV1 reverse transcriptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/28/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 88nMAssay Description:Inhibition of HIV1 reverse transcriptase after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/31/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetReverse transcriptase(Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM50050533(TNK-651 | 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL U...)
Affinity DataIC50: 20nMAssay Description:Inhibition of HIV1 reverse transcriptase using poly(ra)/oligo(dT)15 homopolymer template as substrate after 1 hrMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)