BDBM50067513 CHEMBL3401977

SMILES OP(O)(=O)CC[C@H]1C2CCC(CC2)[C@@H]1Nc1nc(ncc1F)-c1c[nH]c2ncc(F)cc12

InChI Key InChIKey=YQXSREGMIKNZEU-UHFFFAOYSA-N

Data  17 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50067513   

TargetGlycogen synthase kinase-3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  120nMAssay Description:Inhibition of GSK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetRho-associated protein kinase 1/2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  250nMAssay Description:Inhibition of ROCK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase PLK1(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  320nMAssay Description:Inhibition of PLK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  400nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase JAK2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  620nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  850nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi:  3.10E+3nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetHepatocyte growth factor receptor(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PKAa (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetTyrosine-protein kinase SYK(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetInterleukin-1 receptor-associated kinase 4(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2(Human)
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067513(CHEMBL3401977)
Affinity DataKi: >4.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/12/2016
Entry Details Article
PubMed