BDBM50068774 8-HYDROXY-2-METHYL-3-HYDRO-QUINAZOLIN-4-ONE::8-Hydroxy-2-methyl-3H-quinazolin-4-one::8-Hydroxy-2-methyl-3H-quinazolin-4-one (NU1025)::8-hydroxy-2-methylquinazolin-4(3H)-one::CHEMBL123904::NU-1025

SMILES CC1=Nc2c(cccc2O)C(=O)N1

InChI Key InChIKey=YJDAOHJWLUNFLX-UHFFFAOYSA-N

Data  2 KI  1 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50068774   

TargetPoly [ADP-ribose] polymerase 1(Mouse)
Newcastle University

Curated by ChEMBL
LigandPNGBDBM50068774(8-hydroxy-2-methylquinazolin-4(3H)-one | 8-HYDROXY...)
Affinity DataIC50: 400nMAssay Description:Inhibition of the DNA repair Poly (ADP-ribose) polymerase 1, in permeabilised L1210 murine leukemia cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPoly [ADP-ribose] polymerase 1(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50068774(8-hydroxy-2-methylquinazolin-4(3H)-one | 8-HYDROXY...)
Affinity DataKi:  48nMAssay Description:Inhibition of PARP1 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2021
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetPoly [ADP-ribose] polymerase 1(Human)
Nirma University

Curated by ChEMBL
LigandPNGBDBM50068774(8-hydroxy-2-methylquinazolin-4(3H)-one | 8-HYDROXY...)
Affinity DataKi:  52nMAssay Description:Inhibition of human Poly (ADP-ribose) polymerase 1 enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMedPDB3D3D Structure (crystal)