BDBM50075050 Alinia::Nitazoxanide::PH-5776

SMILES CC(=O)Oc1ccccc1C(=O)Nc2ncc(s2)[N+](=O)[O-]

InChI Key InChIKey=YQNQNVDNTFHQSW-UHFFFAOYSA-N

Data  1 KI  8 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50075050   

TargetAldo-keto reductase family 1 member B1(Human)
University of Messina

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 8.22E+3nMAssay Description:Inhibition of human ARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/23/2016
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetBile salt export pump(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/3/2019
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetSignal transducer and activator of transcription 3(Human)
Peking University Health Science Center

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 9.98E+3nMAssay Description:Inhibition of IL-6 induced STAT3 transcriptional activity in human HEK-Blue IL-6 cells assessed as secreted embryonic alkaline phosphatase reporter g...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed
TargetTrehalose-binding lipoprotein LpqY(Mycobacterium tuberculosis (strain ATCC 25618 / H3...)
University of Warwick

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataKd:  8.54E+4nMAssay Description:Binding affinity to RED-NHS labelled Mycobacterium tuberculosis LpqY expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant incub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/19/2023
Entry Details
PubMed
TargetAnoctamin-1(Human)
Peking University

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataIC50: 424nMAssay Description:Inhibition of YFP tagged ANO1 (unknown origin) expressed in FRT cells incubated for 24 hrs by fluorescence plate reader assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2023
Entry Details
PubMed
TargetPyruvate-flavodoxin oxidoreductase(Campylobacter jejuni subsp. jejuni)
University of Virginia Health Systems

Curated by ChEMBL
LigandPNGBDBM50075050(Alinia | Nitazoxanide | PH-5776)
Affinity DataKi:  1.05E+4nMAssay Description:Inhibition of PFOR Campylobacter jejuniMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/23/2020
Entry Details Article
PubMed