BDBM50085531 3,4',5-trihydroxybibenzyl::5-(4-hydroxyphenethyl)benzene-1,3-diol::5-[2-(4-Hydroxy-phenyl)-ethyl]-benzene-1,3-diol::5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol::CHEMBL111234::alpha,beta-dihydro-3,40,5-trihydroxystilbene::dihydroresveratrol

SMILES c1cc(ccc1CCc2cc(cc(c2)O)O)O

InChI Key InChIKey=HITJFUSPLYBJPE-UHFFFAOYSA-N

Data  4 IC50  1 EC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50085531   

TargetLeukotriene A-4 hydrolase(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | dihydroresveratrol | 5...)
Affinity DataIC50: 2.47E+5nMAssay Description:Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetLeukotriene A-4 hydrolase(Human)
Decode Biostructures

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | dihydroresveratrol | 5...)
Affinity DataIC50: 1.45E+5nMAssay Description:Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRAREMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/26/2010
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAromatase(Human)
Purdue University

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | dihydroresveratrol | 5...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of human aromatase using dibenzylfluorescein as substrate preincubated for 30 mins measured after 2 hrs by fluorimetryMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/22/2012
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Hyogo University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | dihydroresveratrol | 5...)
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of human TRPA1 expressed in HEK293 cells assessed as decrease in AITC-induced calcium influx preincubated for 6 mins followed by AITC addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed
TargetTransient receptor potential cation channel subfamily A member 1(Human)
Hyogo University of Health Sciences

Curated by ChEMBL
LigandPNGBDBM50085531(3,4',5-trihydroxybibenzyl | dihydroresveratrol | 5...)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human TRPA1 expressed in HEK293 cells assessed as induction of calcium influx at 30 uM after 6 mins by Fluo-4 dye-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/18/2019
Entry Details Article
PubMed